Figure 2. Deletion of tubular Cpt1a does not markedly impair kidney function in aging.

Representative H&E staining of young and aged Cpt1a^CKO and floxed mice with quantification of tubular injury (see Methods) in the outer and inner cortex (n = 5–6) (A and B). Transdermal glomerular filtration rate (tGFR) measured by FITC-sinistrin (n = 4) (C) and urinary albumin-to-creatinine ratio (ACR) (n = 5) (D) of young and old mice by genotype. Results are shown as the mean ± SD. *P < 0.05, **P < 0.01. Unpaired t test between the 2 genotypes was used to detect statistical significance between the 2 genotypes. For multiple comparisons in C and D, 1-way ANOVA was performed followed by Šidák’s multiple comparisons test. Scale bar: 50 μM.