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. 2024 Apr 18;37:12468. doi: 10.3389/ti.2024.12468

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Copyright © 2024 Shankar, Tejeda-Mora, Du, Nlandu, Palomares-Cabeza, van den Bosch, Korevaar, Da Costa Gonçalves, Bindels, Kramann, Reinders, Clahsen-van Groningen, Hoorn, Gribnau, Baan and Hoogduijn.

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Effect of immune cell infiltration on gene expression of nephron structures and stromal cells. (A) Single cell mRNA expression analysis of tubular structural and functional markers VIL1, CDH1, LRP2 and CUBN, the glomerular markers NPHS1, PODXL and WT1, the DNA damage marker H2AFX and the stress response markers E2F4 and MTOR in nephron cells from organoids with and without infiltrated immune cells. (B) Single cell mRNA expression analysis of stromal markers PDGFRA and PDGFRB, the DNA damage/injury markers H2AFX and BAX and the immune response marker CCL2 in stromal cells from organoids with and without infiltrated immune cells.