Table 2. Composition of SDF-BS Formulations and the Obtained Formulation Attributesa.
| formula | independent variables | responses | |||
|---|---|---|---|---|---|
| X1: SPC (mg) | X2: span 60 (mg) | X3: SDC (mg) | Y1: entrapment efficiency (%) | Y2: vesicle size (nm) | |
| F1 | 200 | 40 | 20 | 53.6 ± 1.7 | 254.3 ± 18.7 |
| F2 | 200 | 50 | 10 | 80.5 ± 1.4 | 174.3 ± 10.1 |
| F3 | 200 | 50 | 30 | 69.3 ± 1.1 | 191.2 ± 20.1 |
| F4 | 200 | 60 | 20 | 88.0 ± 1.5 | 167.1 ± 14.3 |
| F5 | 300 | 40 | 10 | 69.6 ± 1.9 | 206.8 ± 19.6 |
| F6 | 300 | 40 | 30 | 47.3 ± 0.8 | 325.6 ± 21.3 |
| F7 | 300 | 50 | 20 | 77.6 ± 1.8 | 194.6 ± 15.4 |
| F8 | 300 | 50 | 20 | 78.7 ± 1.2 | 205.1 ± 19.5 |
| F9 | 300 | 50 | 20 | 78.1 ± 1.7 | 199.3 ± 13.5 |
| F10 | 300 | 60 | 10 | 91.6 ± 1.2 | 227.7 ± 20.1 |
| F11 | 300 | 60 | 30 | 90.3 ± 1.1 | 189.5 ± 17.6 |
| F12 | 400 | 40 | 20 | 58.6 ± 1.9 | 251.2 ± 15.6 |
| F13 | 400 | 50 | 10 | 86.6 ± 2.1 | 184.7 ± 15.4 |
| F14 | 400 | 50 | 30 | 78.1 ± 1.4 | 254.3 ± 24.1 |
| F15 | 400 | 60 | 20 | 93.9 ± 1.7 | 241.5 ± 22.5 |
a
Each value is the mean ± SD of the three experiments.