Fig. 8.

A) Interaction of mir15a/16-5p cluster and mir-7641 with targeted genes involved in intrinsic and extrinsic signalling pathways of apoptosis. As depicted above, the mir-15a/16 cluster contributes to apoptosis induction by suppressing anti-apoptotic genes such as Bcl-2 and Mc-1. Moreover, miR-16-5p probably inhibits glioma cell viability and invasion through miR-16-5p/Talin-1 (TLN1) Axis. It is worth mentioning that miR-15a and miR-16 can induce apoptosis and cell cycle arrest by suppressing cyclin D1 (CCND1). On the other hand, miR-7641, as an oncogenic miR, promotes tumour cell proliferation by improving intercellular communication. B) Network construction of top differentially expressed miRNAs (DE-miRNAs) and their target mRNAs.