Item No	STROBE items	Location in manuscript where items are reported	RECORD items	Location in manuscript where items are reported
Title and abstract
	1	(a) Indicate the study’s design with a commonly used term in the title or the abstract, (b) provide in the abstract an informative and balanced summary of what was done and what was found	Page 1–3	RECORD 1.1: The type of data used should be specified in the title or abstract. When possible, the names of the databases used should be included RECORD 1.2: If applicable, the geographic region and timeframe within which the study took place should be reported in the title or abstract RECORD 1.3: If linkage between databases was conducted for the study, this should be clearly stated in the title or abstract	Page 1–3
Introduction
Background rationale	2	Explain the scientific background and rationale for the investigation being reported	Page 3–4
Objectives	3	State-specific objectives, including any prespecified hypotheses	Page 4
Methods
Study design	4	Present key elements of study design early in the paper	Page 4
Setting	5	Describe the setting, locations, and relevant dates, including periods of recruitment, exposure, follow-up, and data collection	Page 4–5
Participants	6	(a) Cohort study—give the eligibility criteria, and the sources and methods of selection of participants. Describe methods of follow-up Case–control study—give the eligibility criteria, and the sources and methods of case ascertainment and control selection. Give the rationale for the choice of cases and controls Cross-sectional study—Give the eligibility criteria, and the sources and methods of selection of participants (b) Cohort study—for matched studies, give matching criteria and number of exposed and unexposed Case–control study—for matched studies, give matching criteria and the number of controls per case	Page 4–5	RECORD 6.1: The methods of study population selection (such as codes or algorithms used to identify subjects) should be listed in detail. If this is not possible, an explanation should be provided RECORD 6.2: Any validation studies of the codes or algorithms used to select the population should be referenced. If validation was conducted for this study and not published elsewhere, detailed methods and results should be provided RECORD 6.3: If the study involved the linkage of databases, consider the use of a flow diagram or other graphical display to demonstrate the data linkage process, including the number of individuals with linked data at each stage	Page 4–6
Variables	7	Clearly define all outcomes, exposures, predictors, potential confounders, and effect modifiers. Give diagnostic criteria, if applicable	Page 6	RECORD 7.1: A complete list of codes and algorithms used to classify exposures, outcomes, confounders, and effect modifiers should be provided. If these cannot be reported, an explanation should be provided	Page 7
Data sources/measurement	8	For each variable of interest, give sources of data and details of methods of assessment (measurement) Describe comparability of assessment methods if there is more than one group	Page 6
Bias	9	Describe any efforts to address potential sources of bias	Page 5–6
Study size	10	Explain how the study size was arrived at	Page 6
Quantitative variables	11	Explain how quantitative variables were handled in the analyses. If applicable, describe which groupings were chosen, and why	Page 6
Statistical methods	12	(a) Describe all statistical methods, including those used to control for confounding (b) Describe any methods used to examine subgroups and interactions (c) Explain how missing data were addressed (d) Cohort study—if applicable, explain how loss to follow-up was addressed Case–control study—if applicable, explain how the matching of cases and controls was addressed Cross-sectional study—if applicable, describe analytical methods taking account of sampling strategy (e) Describe any sensitivity analyses	Page 6–7
Data access and cleaning methods				RECORD 12.1: Authors should describe the extent to which the investigators had access to the database population used to create the study population RECORD 12.2: Authors should provide information on the data cleaning methods used in the study	Page 5–6
Linkage				RECORD 12.3: State whether the study included person-level, institutional-level, or other data linkage across two or more databases. The methods of linkage and methods of linkage quality evaluation should be provided	Page 5–6
Results
Participants	13	(a) Report the numbers of individuals at each stage of the study (e.g., numbers potentially eligible, examined for eligibility, confirmed eligible, included in the study, completing follow-up, and analyzed) (b) Give reasons for non-participation at each stage (c) Consider the use of a flow diagram	Page 7	RECORD 13.1: Describe in detail the selection of the persons included in the study (i.e., study population selection) including filtering based on data quality, data availability, and linkage. The selection of included persons can be described in the text and/or by means of the study flow diagram	Page 7
Descriptive data	14	(a) Give characteristics of study participants (e.g., demographic, clinical, social) and information on exposures and potential confounders (b) Indicate the number of participants with missing data for each variable of interest (c) Cohort study—summarize follow-up time (e.g., average and total amount)	Page 7–12
Outcome data	15	Cohort study—Report numbers of outcome events or summary measures over time Case–control study—report numbers in each exposure category, or summary measures of exposure Cross-sectional study—report numbers of outcome events or summary measures	Page 8–14
Main results	16	(a) Give unadjusted estimates and, if applicable, confounder-adjusted estimates and their precision (e.g., 95% confidence interval). Make clear which confounders were adjusted for and why they were included (b) Report category boundaries when continuous variables were categorized (c) If relevant, consider translating estimates of relative risk into absolute risk for a meaningful time period	Page 8–14
Other analyses	17	Report other analyses done—e.g., analyses of subgroups and interactions, and sensitivity analyses	Page 11–13
Discussion
Key results	18	Summarize key results with reference to study objectives	Page 14
Limitations	19	Discuss the limitations of the study, taking into account sources of potential bias or imprecision. Discuss both the direction and magnitude of any potential bias	Page 16–17	RECORD 19.1: Discuss the implications of using data that were not created or collected to answer the specific research question(s). Include discussion of misclassification bias, unmeasured confounding, missing data, and changing eligibility over time, as they pertain to the study being reported	Page 16–17
Interpretation	20	Give a cautious overall interpretation of results considering objectives, limitations, multiplicity of analyses, results from similar studies, and other relevant evidence	Page 17–18
Generalisability	21	Discuss the generalisability (external validity) of the study results	Page 17–18
Other information
Funding	22	Give the source of funding and the role of the funders for the present study and, if applicable, for the original study on which the present article is based	Page 19
Accessibility of protocol, raw data, and programming code				RECORD 22.1: Authors should provide information on how to access any supplemental information such as the study protocol, raw data, or programming code	Page 19