Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 May 2;24:518. doi: 10.1186/s12903-024-04252-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 2 — Analytical procedures and findings pertaining to CDH1 expression and its downstream molecules following diverse treatments, utilizing Western blot and qPCR techniques. (A) Western blot (WB) was employed to monitor the modulation of CDH1 and its downstream proteins after F. nucleatum exposure. Notably, there was an upregulation in the cytoplasmic protein β-catenin, subsequently elevating the levels of Myc and Cyclin D1. (B) Post-genistein treatment analysis revealed an inhibition in CDH1 phosphorylation, ensuring stable expression of CDH1 and its downstream entities. (C) For oncogene expression post F. nucleatum treatment, qPCR was the chosen technique. This assessment highlighted an elevation in oncogene expression after F. nucleatum exposure. (D) Following genistein administration, qPCR outcomes indicated no marked disparities in oncogene expression levels. (*, P<0.05; **, P<0.01; ***, P<0.001.)