Table 2.
Mendelian randomization estimates of years of education on outcome variable
| Outcomes | Method | Estimate-beta | SE | OR(95%CI) | P.value | Adjust P.value |
|---|---|---|---|---|---|---|
| Bone mineral density | IVW | 0.012 | 0.005 | 1.012(1.003,1.022) | 0.011 | 0.014 |
| MR-Egger | 0.044 | 0.022 | 1.045(1.001,1.092) | 0.048 | ||
| Weighted median | 0.012 | 0.004 | 1.012(1.004,1.021) | 0.003 | ||
| Simple median | 0.011 | 0.004 | 1.011(1.003,1.019) | 0.007 | ||
| Whole body fat mass | IVW | -0.051 | 0.006 | 0.950(0.939,0.961) | < 0.001 | < 0.001 |
| MR-Egger | -0.050 | 0.026 | 0.951(0.903,1.001) | 0.006 | ||
| Weighted median | -0.034 | 0.004 | 0.966(0.958,0.975) | < 0.001 | ||
| Simple median | -0.048 | 0.004 | 0.953(0.945,0.961) | < 0.001 | ||
| Whole body lean mass | IVW | -0.007 | 0.004 | 0.993(0.985,1.002) | 0.123 | 0.157 |
| MR-Egger | -0.003 | 0.019 | 0.997(0.960,1.035) | 0.876 | ||
| Weighted median | -0.009 | 0.003 | 0.991(0.984,0.998) | 0.008 | ||
| Simple median | -0.012 | 0.003 | 0.988(0.982,0.994) | < 0.001 | ||
| Sunbath | IVW | -0.013 | 0.001 | 0.987(0.986,0.989) | < 0.001 | < 0.001 |
| MR-Egger | -0.008 | 0.004 | 0.992(0.984,1.001) | 0.068 | ||
| Weighted median | -0.013 | 0.001 | 0.987(0.985,0.989) | < 0.001 | ||
| Simple median | -0.014 | 0.001 | 0.986(0.984,0.988) | < 0.001 | ||
| Physical activity | IVW | 0.145 | 0.058 | 1.156(1.032,1.295) | 0.012 | 0.017 |
| MR-Egger | -0.258 | 0.248 | 0.773(0.475,1.257) | 0.299 | ||
| Weighted median | 0.128 | 0.063 | 1.136(1.004,1.287) | 0.043 | ||
| Simple median | 0.172 | 0.062 | 1.188(1.051,1.342) | 0.005 | ||
| Time for light physical activity | IVW | -0.480 | 0.496 | 0.618(0.233,1.636) | 0.333 | 0.409 |
| MR-Egger | 0.566 | 2.140 | 1.761(0.026,116.870) | 0.792 | ||
| Weighted median | -0.457 | 0.707 | 0.633(0.158,2.533) | 0.519 | ||
| Simple median | -0.506 | 0.723 | 0.603(0.146,2.484) | 0.483 | ||
| Time for moderate physical activity | IVW | -0.002 | 0.009 | 0.998(0.979,1.016) | 0.835 | 0.971 |
| MR-Egger | 0.061 | 0.040 | 1.063(0.982,1.150) | 0.130 | ||
| Weighted median | -0.006 | 0.013 | 0.994(0.968,1.020) | 0.651 | ||
| Simple median | -0.005 | 0.014 | 0.995(0.969,1.022) | 0.727 | ||
| Time for vigorous physical activity | IVW | -0.045 | 0.009 | 0.955(0.939,0.972) | < 0.001 | < 0.001 |
| MR-Egger | -0.011 | 0.038 | 0.989(0.918,1.065) | 0.779 | ||
| Weighted median | -0.043 | 0.012 | 0.957(0.934,0.981) | < 0.001 | ||
| Simple median | -0.044 | 0.012 | 0.957(0.935,0.980) | < 0.001 | ||
| Falling risk | IVW | -0.024 | 0.006 | 0.976(0.965,0.987) | < 0.001 | < 0.001 |
| MR-Egger | -0.003 | 0.025 | 0.997(0.949,1.047) | 0.911 | ||
| Weighted median | -0.025 | 0.007 | 0.975(0.961,0.989) | < 0.001 | ||
| Simple median | -0.031 | 0.007 | 0.969(0.956,0.983) | < 0.001 | ||
| Salt consumption | IVW | -0.035 | 0.003 | 0.965(0.959,0.971) | < 0.001 | < 0.001 |
| MR-Egger | -0.019 | 0.014 | 0.981(0.953,1.009) | 0.186 | ||
| Weighted median | -0.031 | 0.003 | 0.969(0.963,0.975) | < 0.001 | ||
| Simple median | -0.033 | 0.003 | 0.967(0.961,0.974) | < 0.001 | ||
| Smoking | IVW | -0.031 | 0.003 | 0.969(0.964,0.975) | < 0.001 | < 0.001 |
| MR-Egger | -0.026 | 0.013 | 0.974(0.950,0.998) | 0.040 | ||
| Weighted median | -0.029 | 0.002 | 0.971(0.966,0.976) | < 0.001 | ||
| Simple median | -0.031 | 0.003 | 0.969(0.964,0.974) | < 0.001 | ||
| Coffee intake | IVW | 0.019 | 0.003 | 1.019(1.014,1.024) | < 0.001 | < 0.001 |
| MR-Egger | 0.019 | 0.011 | 1.019(0.997,1.041) | 0.085 | ||
| Weighted median | 0.017 | 0.002 | 1.017(1.011,1.022) | < 0.001 | ||
| Simple median | 0.018 | 0.003 | 1.018(1.012,1.023) | < 0.001 | ||
| Fizzy drink intake | IVW | -0.014 | 0.004 | 0.985(0.978,0.992) | 0.0001 | 0.0002 |
| MR-Egger | -0.019 | 0.016 | 0.980(0.949,1.012) | 0.223 | ||
| Weighted median | -0.015 | 0.006 | 0.985(0.974,0.996) | 0.008 | ||
| Simple median | -0.017 | 0.005 | 0.982(0.972,0.993) | 0.002 | ||
| Calcium consumption | IVW | 0.004 | 0.001 | 1.004(1.002,1.005) | < 0.001 | < 0.001 |
| MR-Egger | 0.007 | 0.003 | 1.007(1.001,1.012) | 0.017 | ||
| Weighted median | 0.005 | 0.001 | 1.005(1.003,1.007) | < 0.001 | ||
| Simple median | 0.004 | 0.001 | 1.004(1.003,1.006) | < 0.001 | ||
| Milk intake | IVW | -0.002 | 0.003 | 0.998(0.993,1.003) | 0.436 | 0.528 |
| MR-Egger | 0.007 | 0.011 | 1.007(0.985,1.029) | 0.516 | ||
| Weighted median | -0.004 | 0.003 | 0.995(0.988,1.003) | 0.279 | ||
| Simple median | -0.004 | 0.004 | 0.996(0.988,1.003) | 0.286 | ||
| Alcohol intake | IVW | 0.038 | 0.019 | 1.038(0.999,1.079) | 0.056 | 0.075 |
| MR-Egger | 0.069 | 0.089 | 1.071(0.898,1.278) | 0.442 | ||
| Weighted median | 0.056 | 0.028 | 1.057(0.999,1.119) | 0.051 | ||
| Simple median | 0.043 | 0.029 | 1.044(0.985,1.106) | 0.145 |
beta allele effect value, se standard error, OR odds ratio, CI confidence interval, MR Mendelian randomization, IVW inverse variance weighted