TABLE 2.
In vitro activity of sulbactam-durlobactam against resistant subsets of ABC baseline isolates from ATTACKa
| Category | ABC baseline isolates, N (%) | SUL-DUR MIC range (µg/mL) | SUL-DUR MIC50/90 (µg/mL) |
|---|---|---|---|
| ALL | 175 (100) | 0.25–16 | 2/4 |
| CARB-R | 168 (96) | 0.5–16 | 2/4 |
| MDR | 168 (96) | 0.5–16 | 2/4 |
| XDR | 148 (85) | 0.5–16 | 2/4 |
| PDR | 26 (15) | 1–8 | 2/4 |
CARB‑R = carbapenem-resistant (MIC > 4 µg/mL); MDR = non-susceptible to at least three different antibiotic classes used to treat ABC; PDR = non-susceptible to all tested antibiotic classes approved for use to treat ABC; XDR = non‑susceptible to all but two antibiotic classes approved for use to treat ABC (13). Sulbactam-durlobactam was tested as a titration of sulbactam in the presence of 4 µg/mL durlobactam.