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. 2024 Apr 3;68(5):e01698-23. doi: 10.1128/aac.01698-23

TABLE 2.

In vitro activity of sulbactam-durlobactam against resistant subsets of ABC baseline isolates from ATTACKa

Category ABC baseline isolates, N (%) SUL-DUR MIC range (µg/mL) SUL-DUR MIC50/90 (µg/mL)
ALL 175 (100) 0.25–16 2/4
CARB-R 168 (96) 0.5–16 2/4
MDR 168 (96) 0.5–16 2/4
XDR 148 (85) 0.5–16 2/4
PDR 26 (15) 1–8 2/4
a

CARB‑R = carbapenem-resistant (MIC > 4 µg/mL); MDR = non-susceptible to at least three different antibiotic classes used to treat ABC; PDR = non-susceptible to all tested antibiotic classes approved for use to treat ABC; XDR = non‑susceptible to all but two antibiotic classes approved for use to treat ABC (13). Sulbactam-durlobactam was tested as a titration of sulbactam in the presence of 4 µg/mL durlobactam.