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. 2024 Apr 3;68(5):e01698-23. doi: 10.1128/aac.01698-23

TABLE 3.

In vitro susceptibility of 175 ABC baseline isolates in ATTACK to sulbactam, durlobactam, and imipenem alone or in combinationa

Antibacterial agent or combination MIC range (µg/mL) MIC50
(µg/mL)
MIC90
(µg/mL)
Sulbactam 0.25 to >64 32 64
Durlobactam 0.25 to >64 64 >64
Sulbactam-durlobactam 0.25–32 2 4
Imipenem 0.12 to >64 64 >64
Imipenem-durlobactam 0.12–64 16 32
Sulbactam-imipenem (1:1) 0.12–64 16 32
Sulbactam-imipenem (1:1) + durlobactam 0.12–16 1 4
a

Durlobactam was held at a fixed concentration of 4 µg/mL in all combinations tested.