TABLE 3.
In vitro susceptibility of 175 ABC baseline isolates in ATTACK to sulbactam, durlobactam, and imipenem alone or in combinationa
| Antibacterial agent or combination | MIC range (µg/mL) | MIC50 (µg/mL) |
MIC90 (µg/mL) |
|---|---|---|---|
| Sulbactam | 0.25 to >64 | 32 | 64 |
| Durlobactam | 0.25 to >64 | 64 | >64 |
| Sulbactam-durlobactam | 0.25–32 | 2 | 4 |
| Imipenem | 0.12 to >64 | 64 | >64 |
| Imipenem-durlobactam | 0.12–64 | 16 | 32 |
| Sulbactam-imipenem (1:1) | 0.12–64 | 16 | 32 |
| Sulbactam-imipenem (1:1) + durlobactam | 0.12–16 | 1 | 4 |
Durlobactam was held at a fixed concentration of 4 µg/mL in all combinations tested.