. 2024 Mar 27;68(5):e01686-23. doi: 10.1128/aac.01686-23

TABLE 2.

Antimicrobial susceptibility of omadacycline and comparators against various Nocardia species^c

Species	No. tested	OMC^a		TGC^a		MIN			SXT	LZD	AXO	IMI	AMI	CIP
		MIC₅₀^b	MIC₉₀	MIC₅₀	MIC₉₀	MIC₅₀	MIC₉₀	% S	% S	% S	% S	% S	% S	% S
N. abscessus complex	16	0.5	1	0.25	0.5	0.5	1	100	100	100	100	25	100	0
N. asiatica	10	0.25	1	0.25	1	0.25	0.5	100	100	100	90	70	100	0
N. beijingensis	10	0.5	2	1	2	0.25	1	100	100	100	100	90	100	0
N. brasiliensis	19	2	2	0.25	0.5	1	4	52.6	100	100	52.6	5.3	100	5.3
N. cyriacigeorgica	64	2	4	1	2	2	4	14.1	100	100	84.4	82.8	98.4	0
N. farcinica	36	4	8	4	4	2	4	0	97.2	100	2.8	44.4	100	47.2
N. nova	59	4	4	1	2	2	4	20.3	100	100	66.1	98.3	100	0
N. otitidiscaviarum	11	1	2	0.5	1	1	2	54.5	100	100	0	0	100	0
N. paucivorans	11	0.25	0.25	0.25	0.5	0.25	0.25	100	100	100	100	100	100	100
N. veterana	14	4	4	2	4	2	4	14.3	100	100	35.7	100	100	0
N. wallacei	12	4	4	2	4	2	2	33.3	75	100	75	8.3	41.7	100
Nocardia species^d	38	2	4	0.5	4	2	4	39.5	100	100	65.8	52.6	94.7	26.3
Total Nocardia isolates	300	2	4	1	4	2	4	35	98.7	99.7	63	64.7	96.7	17

^{^a}

There are no breakpoint interpretations for omadacycline and tigecycline against Nocardia species in the CLSI M24S-2; therefore, only the MIC₅₀ and MIC₉₀ are reported.

^{^b}

MIC values are reported in units of µg/mL.

^{^c}

OMC: omadacycline, MIN: minocycline, TGC: tigecycline, SXT: trimethoprim-sulfamethoxazole, LZD: linezolid, CIP: ciprofloxacin, IMI: imipenem, AXO: ceftriaxone, CIP: ciprofloxacin, AMI: amikacin.

^{^d}

Nocardia species includes species with ≤6 isolates and Nocardia spp. that could not be identified to species level. This group consisted of N. vulneris (n = 6), N. asteroides (n = 4), N. transvalensis complex (n = 4), N. africana/nova (n = 3), N. pseudobrasiliensis (n = 3), N. brasiliensis/vulneris (n = 2), N. farcinica/kroppenstedtii (n = 2), N. africana (n = 1), N. amikacinoitolerans (n = 1), N. araoensis (n = 1), N. araoensis/niwae (n = 1), N. carnaea (n = 1), N. grenadensis (n = 1), N. rhamnosiphila (n = 1), N. sienata (n = 1), N. thailandica (n = 2), N. vinacea (n = 1), and Nocardia spp. (n = 3).