TABLE 4.
Diagnostic performance measures for the three tests on farms cattle considering coprological examination as the gold standard method (n = 433, 28 positive cases). Cattle diagnosed with other than parasites than F. hepatica (n = 67) were excluded from the analysesa
| Performance measures | Native antigens | Recombinant antigen | |
|---|---|---|---|
|
FhES estimate (95% CI) |
FhSA estimate (95% CI) |
FhrCL-1 estimate (95% CI) |
|
| Cutoff | 0.4105 (OD) | 0.4830 (OD) | 0.1270 (OD) |
| Sensitivity | 22/28 (0.79) (0.60–0.90) |
20/28 (0.71) (0.52–0.85) |
16/28 (0.57) (0.39–0.74) |
| Specificity | 347/405 (0.86) (0.82–0.89) |
285/405 (0.70) (0.66–0.75) |
304/405 (0.75) (0.71–0.79) |
| PPV | 22/80 (0.28) (0.22–0.34) |
20/140 (0.14) (0.11–0.18) |
16/117 (0.14) (0.10–0.19) |
| NPV | 347/353 (0.98) (0.97–0.99) |
285/293 (0.97) (0.95–0.98) |
304/316 (0.96) (0.94–0.97) |
a
CI= Confidence Intervals; PPV= Positive Predictive Values; NPV= Negative Predictive Values; OD= Optical Density.