Table 3. Adjusted a risk estimates of lung cancer associated with categorical (quartiles of silica exposure) and log-cumulative silica exposure, derived using the original SYN-JEM (JEM 1)), and different SYN-JEM specifications with varying dimensions of SYN-JEM included (JEM 2-5). [OR=odds ratio; 95% CI=95% confidence interval; AIC=Akaike Information Criterion. Ntot=37866]. Cut-offs for exposure quartiles are based on the JEM specific distribution of exposure among the controls.
| JEM 1: SYN-JEM | JEM 2: SYN-JEM without region-specific estimates | JEM 3: SYN-JEM without job-specific estimates | JEM 4: SYN-JEM without region- or job-specific estimates | JEM 5: SYN-JEM without DOM-JEM prior (with nonexposed override) | |||||
|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | |||||
| Cumulative silica exposure (mg/m3-years): | |||||||||
| Unexposed | 1 | 1 | 1 | 1 | 1 | ||||
| 1st quartile | 1.15 (1.04-1.27) | 1.16 (1.05-1.28) | 1.13 (1.02-1.25) | 1.16 (1.05-1.27) | 1.13 (1.02-1.25) | ||||
| 2nd quartile | 1.33 (1.21-1.47) | 1.29 (1.17-1.42) | 1.35 (1.23-1.49) | 1.27 (1.15-1.41) | 1.34 (1.22-1.48) | ||||
| 3rd quartile | 1.29 (1.17-1.42) | 1.30 (1.18-1.43) | 1.32 (1.20-1.46) | 1.34 (1.21-1.47) | 1.29 (1.17-1.42) | ||||
| 4th quartile | 1.45 (1.31-1.60) c | 1.50 (1.37-1.66) c | 1.42 (1.29-1.57) c | 1.48 (1.34-1.64) c | 1.46 (1.33-1.61) c | ||||
| Log-cumulative silica exposure: b | |||||||||
| β-coefficient | 1.049 (1.039-1.059) | 1.048 (1.039-1.058) | 1.050 (1.040-1.061) | 1.050 (1.040-1.060) | 1.047 (1.037-1.057) |
a Adjusted for age group, sex, study, cigarette pack-years, time-since-quitting smoking, and ever-employment in a ‘list A job’. b To enable log-transformation of exposure data generated with JEM 1-5, unexposed study participants were assigned two thirds of the lowest exposure value obtained using JEM 1 (0.0036 mg/m3-years). c p trend<0.001