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. 2024 May;65(5):761–767. doi: 10.2967/jnumed.123.266309

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© 2024 by the Society of Nuclear Medicine and Molecular Imaging.

Immediate Open Access: Creative Commons Attribution 4.0 International License (CC BY) allows users to share and adapt with attribution, excluding materials credited to previous publications. License: https://creativecommons.org/licenses/by/4.0/. Details: http://jnm.snmjournals.org/site/misc/permission.xhtml.

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FIGURE 3. — Uptake and treatment effect of [¹⁷⁷Lu]Lu-DPI-4452 in subcutaneous HT-29 and SK-RC-52 human xenograft mouse models. (A and B) Growth of HT-29 (A) and SK-RC-52 (B) xenografts treated with single doses of vehicle, 100 or 33 MBq of [¹⁷⁷Lu]Lu-DPI-4452, or 3 once-weekly (QW × 3) 33 MBq doses of [¹⁷⁷Lu]Lu-DPI-4452. Arrowheads indicate days of treatment (n = 10 per group). (C and D) Tumor uptake (percentage injected dose per gram of tissue, %ID/g) for HT-29 (C) and SK-RC-52 (D) xenografts at 4 h after injection (n = 3 per group). Shown are mean (bar) and individual values.