TABLE 4.
Plasma Pharmacokinetics of DPI-4452 in Mice and Dogs
| Animal | Dose (mg/kg) | AUCinf (h·ng/mL) | C5 min (ng/mL) | tlast (h) | Clearance (mL/min/kg) | Vss (L/kg) | Half-life (h) |
|---|---|---|---|---|---|---|---|
| Mouse | 0.7 | 424 | 1,380 | 2 | 27.5 | 0.41 | 0.28 |
| 5.5 | 2,820 | 9,270 | 4 | 32.5 | 0.46 | 0.47 | |
| Beagle dog | 0.1 | 133 | 377 | 2 | 12.7 | 0.26 | 0.38 |
| 0.8 | 1,760 | 4,430 | 4 | 7.6 | 0.19 | 0.48 |
AUCinf = area under plasma concentration–time curve extrapolated to infinity; C5 min = measured concentration at 5 min after injection; tlast = time to last measurable concentration; Vss = volume of distribution at steady state.