TABLE 6.
Dose (mg/kg) | Sex | C5 min (ng/mL)* | tlast (h)† | AUCinf (h·ng/mL)* | AUCinf/dose (h·ng/mL)/(μg/kg)* |
---|---|---|---|---|---|
0.016 | Female | 37.7 (6.83) | 1 (1–1) | 12.4 (2.13) | 0.774 (0.133) |
Male | 43.5 (2.75) | 1 (1–1) | 14 (1.29) | 0.873 (0.0806) | |
0.08 | Female | 346 (34.8) | 3 (2–3) | 144 (15.3) | 1.8 (0.192) |
Male | 332 (14.7) | 2 (2–3) | 132 (5.49) | 1.65 (0.0687) | |
0.4 | Female | 1,760 (180) | 3 (3–3) | 771 (40.6) | 1.93 (0.101) |
Male | 1,840 (257) | 3 (3–3) | 854 (120) | 2.13 (0.3) |
Reported as mean, with SD in parentheses.
Reported as median, with range (minimum to maximum) in parentheses.
C5 min = measured concentration at 5 min after injection; tlast = time to last measurable concentration; AUCinf = area under plasma concentration–time curve extrapolated to infinity.