TABLE 7.
Calculated Absorbed Doses to Organs of [68Ga]Ga-DPI-4452 and [177Lu]Lu-DPI-4452 for Human ICRP-89 Phantoms
| [68Ga]Ga-DPI-4452 (Gy/GBq) | [177Lu]Lu-DPI-4452 (Gy/GBq) | |||
|---|---|---|---|---|
| Target organ | Female | Male | Female | Male |
| Adrenals | 1.52E−02 | 1.20E−02 | 1.56E−01 | 1.15E−01 |
| Brain | 1.09E−02 | 8.93E−03 | 1.41E−01 | 1.00E−01 |
| Breasts | 1.07E−02 | 1.39E−01 | ||
| Esophagus | 1.17E−02 | 1.00E−02 | 1.43E−01 | 1.06E−01 |
| Eyes | 1.09E−02 | 8.95E−03 | 1.41E−01 | 1.00E−01 |
| Gallbladder wall | 1.80E−02 | 1.38E−02 | 2.89E−01 | 2.62E−01 |
| Left colon | 2.41E−02 | 1.94E−02 | 3.66E−01 | 2.73E−01 |
| Small intestine | 8.85E−02 | 6.62E−02 | 6.95E−01 | 5.31E−01 |
| Stomach wall | 7.19E−02 | 3.51E−02 | 8.24E−01 | 7.14E−01 |
| Right colon | 2.28E−02 | 1.85E−02 | 3.66E−01 | 2.72E−01 |
| Rectum | 3.89E−02 | 2.58E−02 | 1.50E−01 | 1.07E−01 |
| Heart wall | 1.77E−02 | 1.49E−02 | 1.47E−01 | 1.07E−01 |
| Kidneys | 2.16E−02 | 1.49E−02 | 4.38E−01 | 3.10E−01 |
| Liver | 1.18E−02 | 8.60E−03 | 2.90E−01 | 3.12E−01 |
| Lungs | 6.26E−03 | 4.48E−03 | 6.07E−02 | 4.63E−02 |
| Ovaries/testes | 2.08E−02 | 7.56E−03 | 1.71E−01 | 1.89E−02 |
| Pancreas | 1.64E−02 | 1.32E−02 | 1.57E−01 | 1.16E−01 |
| Salivary glands | 1.13E−02 | 9.65E−03 | 1.42E−01 | 1.02E−01 |
| Red marrow | 1.37E−02 | 1.01E−02 | 1.34E−01 | 9.88E−02 |
| Osteogenic cells | 9.98E−03 | 8.75E−03 | 1.36E−01 | 1.26E−01 |
| Spleen | 1.50E−02 | 1.09E−02 | 1.53E−01 | 1.08E−01 |
| Thymus | 1.19E−02 | 9.66E−03 | 1.43E−01 | 1.02E−01 |
| Thyroid | 1.12E−02 | 9.56E−03 | 1.41E−01 | 1.02E−01 |
| Urinary bladder wall | 5.33E−01 | 4.73E−01 | 4.76E−01 | 3.56E−01 |
| Uterus/prostate | 3.23E−02 | 2.31E−02 | 1.52E−01 | 1.06E−01 |
| Total body | 1.71E−02 | 1.38E−02 | 1.68E−01 | 1.23E−01 |