Table 1.
Large available genome-wide association studies and previous publications used to identify single nucleotide polymorphisms associated with systemic inflammatory markers.
| Marker | Author of GWAS/Instrument | Sample size | Outcome | SNPs Identified | SNPs available on each chip |
|---|---|---|---|---|---|
| Primary analysis | |||||
| CRP | (Said et al., 2022) | 575,531 | Circulating CRP | 19 | 16 |
| IL-6R | (Ahluwalia et al., 2021) | 52,654 | Circulating IL-6 | 2 | 2 |
| (Sarwar et al., 2012) | 27,185 | Circulating IL-6 | 1 | 1 | |
| sIL6R | (Rosa et al., 2019) | 3,301 | Circulating sIL6R | 34 | 34 |
| GlycA | (Borges, 2020) | 115,078 | Circulating GlycA | 87 | 73–74 |
| Secondary analysis | |||||
| CRP | (Said et al., 2022) | 575,531 | Circulating CRP | 485 | 445–446 |
| IL-6 | (Ahluwalia et al., 2021) | 52,654 | Circulating IL-6 | 3 | 2–3 |
CRP = C-reactive protein; IL-6 = interleukin-6, IL-6R = IL-6 receptor, sIL6R = soluble IL-6R