Table 2.
Lifelines Cohort Sample Characteristics at Baseline and First Follow-up Assessment
| Measures | Cohort Analyses (n = 147,815) |
Genetic Analyses (n = 58,713) |
|---|---|---|
| Baseline Assessment | ||
| Age [Mean (SD)] | 44.52 (13.12) n = 147,815 |
43.04 (13.56) n = 58,713 |
| Sex (% Female) | 59 % n = 147,815 |
60% n = 58,695 |
| Education (N %) | n = 146,050 | n = 58,112 |
| Lower | 43,750 (30%) | 16,359 |
| Moderate | 57,785 (40%) | 23,770 |
| Higher | 44,515 (30%) | 17,983 |
| Body mass index | 26.05 (4.34) n = 147,719 |
25.81 (4.27) n = 58,680 |
| RFFT (Unique designs) [Mean (SD)] | 81.50 (22.94) n = 88,096 |
82.46 (23.01) n = 36,563 |
| Any Depressive Disorder (Current Major Depression or Dysthymia) | 3.4% n = 141,045 |
2.9% n = 56,861 |
| Major Depressive Episode (Current) | 2.1% n = 141,538 |
1.8% n = 57,048 |
| Any Anxiety Disorder (panic disorder, agoraphobia, social phobia, or GAD ) | 7.8% n = 141,538 |
7.2% n = 57,048 |
| Generalized Anxiety Disorder | 4.2% n = 141,539 |
3.8% n = 57,048 |
| Negative Affect Score [Mean (SD)] | 20.71 (13.12) n = 139,217 |
20.70 (5.22) n = 57,964 |
| Positive Affect Score [Mean (SD)] | 35.37 (4.25) n = 139,217 |
35.37 (4.19) n = 57,964 |
| C-reactive protein level (mg/L), [Median (IQR), Mean (SD)] | 1.2 (.60, 2.80), 2.61 (4.76) n = 55,098 |
1.2 (2.2) 2.62 (4.60) n = 23,607 |
| First follow up | ||
| Any Depressive Disorder (Current Major Depression or Dysthymia) | 4.1% n = 77,758 |
Not used |
| Major Depressive Episode (Current) | 3.0% n = 77,758 |
Not used |
| Any Anxiety Disorder (panic disorder, agoraphobia, social phobia, or GAD ) | 8.3% n = 77,758 |
Not used |
| Generalized Anxiety Disorder | 5.9% n = 77,758 |
Not used |
| Cogstate: Episodic Memory (Accuracy), Mean (SD) | 0.96 (0.12) n = 84,819 |
0.96 (0.12) n = 36,798 |
| Cogstate: Working Memory (Accuracy), Mean (SD) | 1.31 (0.19) n = 83,721 |
1.32 (0.19) n = 36,363 |
| Cogstate: Visual Attention (Response Time), Mean (SD) | 2.69 (0.09) n = 82,175 |
2.68 (0.09) n = 35,743 |
| Cogstate: Psychomotor Speed (Response Time), Mean (SD) | 2.56 (0.16) n = 81,139 |
2.55 (0.16) n = 35,314 |
Lower = no education, primary education, lower/preparatory vocational education, lower general secondary education; Moderate = intermediate vocational education/apprenticeship, higher secondary education; Higher = higher vocational education, university; IQR = Inter Quartile Range.