Table 4. Associations of CRP levels with affect, depressive and anxiety disorders, and cognitive task performance in the Lifelines cohort.

Please note: point estimates do not include 95% confidence intervals (and N, p-value) as we do not currently have access to the Lifelines Cohort Workspace, the Cohort will allow us access to data for response to reviewer comments, we will add these (p-value, 95% CI, N) as necessary during review.

	Baseline							Follow-up
Predictors	MDD	Any DEP	GAD	Any ANX	Negative Affect	Positive Affect	RFFT	MDD	Any DEP	GAD	Any ANX	Psycho motor Speed	Attention	Episodic Memory	Working Memory
	Odd’s Ratio				Standardized regression coefficient			Odd’s Ratio				Standardized regression coefficient
Model 1 (Unadjusted analysis)
CRPa	1.59	1.57	1.24	1.29	.03	−.05	−.07	1.43	1.42	1.26	1.22	.03	.03	−.03	−.03
Model 2 (Adjusted for age, sex, education, health status, and BMI)
CRPa	1.02†	1.22	1.01†	1.06†	.01	−.04	−.03	1.06†	1.07†	1.05†	1.03†	.01	.01	0†	−.01†
Age	.98	.98	.98	.99	−.06	0†	−.24	.97	.97	.97	.98	.38	.38	−.14	−.17
Female	1.53	1.59	1.56	1.66	.17	0†	.04	1.28	1.33	1.58	1.6	.01†	.01†	0†	−.01
Education: High	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref
Education: Moderate	1.62	1.76	1.3	1.28	.04	−.04	−.19	1.39	1.31	1.1†	1.12	.07	.07	−.13	−.08
Education: Low	2.94	3.02	1.64	1.72	.11	−.11	−.35	2.16	1.84	1.26	1.3	.16	.16	−.22	−.18
Health Status: O Dx	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref
Health Status: 1 Dx	1.83	1.64	1.55	1.43	.04	−.01	−.02	1.5	1.5	1.36	1.29	0†	0†	0†	−.01†
Health Status: 2 Dx	2.97	2.63	2.26	1.82	.04	0†	−.02	2.5	2.34	1.67	1.47	0†	0†	−.01	−.02
Health Status: 3+ Dx	4.24	3.76	2.82	2.65	.02	−.01	−.01	3.71	3.28	2	1.67	0†	0†	−.01	0†
BMI	1.04	1.03	1.01	1.01	0†	0†	0†	1.05	1.04	1.02	1.02	0†	0†	−.03	−.01†

CRP = C-reactive Protein; MDD = Major Depressive Disorder; Any DEP = MDD or Dysthymia; GAD = Generalized Anxiety Disorder; Any ANX = panic disorder, agoraphobia, social phobia, or GAD; RFFT = Ruff Figural Fluency Test;

^a= log-transformed variable; BMI = Body Mass Index; Ref = Reference Category for categorical variables;

^†= p >.05; Odds ratios are reported in logistic regression predicting binary outcomes and standardized beta coefficients are reported for linear regression; For values ≤ .001 and ≥−.001, values were rounded to 0.