Figure 2. Comparison of the diversity of gut microbiota in multi-trajectories of different sex.

(A&B) alpha -diversity analysis between males (A) and females (B). Four alpha-diversity indices were scaled: Shannon’s diversity index, observed-features, Pielou’s measure of species evenness and faith’s phylogenetic diversity. Comparison between each risk trajectory group and the normal group using Kruskal Wallis test. (C-F) β-diversity analysis between males (C, D, F) and females (E). Pairwise comparisons were determined by PERMANOVA analyses based on Bray-Curtis distance. R² and p value were determined from 999 permutations.