Table 1. Dopamine transporter radiotracers according to the literature.

Tracer	Isotope	Scan time (min.)	Peak striatal activity (min.)	Signal to noise ratio	SERT: DAT	PET/SPECT	References
Cocaine	[11C]	10-20	4-7	< 2	Almost equal affinity	PET	Ritz et al., 199045 Logan et al., 199046 Telang et al., 199947
CFT	[11C]	60-90	225	5	>12-fold Ki 12.6	PET	Frost et al., 199313 Rinne et al., 199948,49 Madras et al., l98950 Morris et al., 199651 Haaparanta et al., 199652 Brownell et al., 199653
CFT	[l8F]	120	225	10	4-l6 DAT:SERT	PET	Haaparanta et al., 199652
WIN 35,428	[3H]	NA	NA	NA	NA	PET	Gatley et al., 199554
β-CIT or RTI 55 dopa scan	[123I]	1440	900-1200	9	1.6	SPECT	Innis et al., 199319 Laruelle et al., 199455 Brucke et al., 199356 Laruelle et al, 199457
FE or FP-CIT	[123I] [11C] [18F]	70-240	30	8	Same β-CIT	PET: SPECT	Kuikka et al., 199558 Antonini et al., 200159 Tissing et al, 199860 Booij et al., 200161 Lundkvist et al., 199762 Chaly et al., 199663 Abi-Dargham et al., 199664
Altropane	[123I] [11C]	60-1 20	10-15	~6	25-fold DAT. Sert selectivity Ki 6.8	SPECT PET	Madras et al, 199839,65,66 Fischman et al., 199867 Elmaleh et al., 199668
PE2I or RTI-32	[123I]	8 -70	~70	8	high affinity (Ki =17 nM) and selectivity for DAT	SPECT PET	Emond et al., 199769 Chalon et al., 199970 Hall et al., 199971 Guilloteau et al., 199872 Poyot et al., 200173 Kuikka et al., 199974 Repo et al., 199975
TRODAT-1	[99mTc]	240	180-240	2.5	Ki = l2 nM	SPECT	Choi et al., 199976 Acton et al., 199977 Kao et al., 200178
D-threo-methylphenidate	[11C]	30	15	2-3	Ki = 12 nM DAT	PET	Gatley et al., 199554 Volkow et al., 199532 Lee et al., 200079

CFT = 2beta-carbomethoxy-3betafluorophenyl-tropane;WIN = [11C]2beta-carbomethoxy-3beta-(4-fluorophenyl)-tropane; β-CIT = 2b-carboxymethoxy3b-[4-iodophenyl] tropane; RTI = [1R-(exo,exo)]- 3-[4-(iodo123)phenyl]-8-methyl-8-azabicyclo[3.2.1]o ctane-2-carb oxylic acid methyl ester; FE-CIT = ioflupane; FP-CIT = N-[3-fluoropropyl]-2ss-carbomethoxy-3ss-[4-iodophenyl]nortropane; PE2I = N-{3-iodoprop-(2E)-enyl}-2beta-carboxymethoxy-3beta-{4'methylphenyl}nortropane; RTI-32 = methyl (1R-2-exo-3-exo)-8-methyl-3-(4-methylphenyl)-8-azabicyclo[3.2.1]octane-2-carboxylate; TRODAT-1 = [2-[[2-[[[3-(4-chloro- phenyl)-8-methyl-8-azabicyclo[3, 2, 1]oct-2-yl]methyl] (2-mercaptoethyl)amino]ethyl]amino]ethanethiolato(3)]-oxo-[1R-(exo -exo)]; NA = not available; DAT = dopamine transporter; SERT = serotonin transporter; PET = photon emission tomography; SPECT = single photon emission computerized tomography.