Extended Data Fig. 3 |. Base edits with strong functional effects are enriched in structured regions of proteins.

Scatter plot showing the correlation between AlphaFold predicted local Distance Difference Test (pLDDT) scores and screen LFC (log2-fold changes) for residues in proteins whose genes had |LFC | > 1.0 in the TNFα screen. Lower (<50) AlphaFold pLDDTs scores are predictive of structurally disordered regions of proteins. Predictions were obtained from pre-computed AlphaFold structures for canonical UniProt accessions for each screen gene.