Table 3.

Applications of [^99mTc]Tc-FAPI tracers in inflammation

Author	Year/country	Compound	Administered activity	Imaging protocol	Clinical setting	Patient cohort	Comment
Liu et al. (2023a, b, )	2023/China	HFAPI	695.6–888.0 MBq	Biodistribution: WB at whole-body scintigraphy at 5 min, 20 min, 40 min, 1 h, 2 h, 3 h, 4 h, and 6 h Diagnostics: chet SPECT/CT at 4 h	Idiopathic pulmonary fibrosis	11	[99mTc]Tc-HFAPI SPECT/CT showed promising results for detecting and scoring IPF severity, with good correlation with HRCT and clinical parameters
Xie et al. (2023)	2023/China	HFAPI	777 ± 140 MBq	Cardiac SPECT/CT at 195 ± 20 min	Early myocardial fibrosis	106 (20 gender-matched healthy controls)	[99mTc]Tc-HFAPI SPECT might have role of detect early-stage myocardial fibrosis in hypertensive patients