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. 2024 May 2;10:214. doi: 10.1038/s41420-024-01982-9

Fig. 7. Effect of the main components of NETs on the biological behavior of OSCC cells.

Fig. 7

A, B After inhibiting NE, MMP 9 and CG in NETs, western blot was used to detect the EMT-related markers and NLRP3 in Cal27 and HN6 cells. C, D After inhibiting NE, MMP 9 and CG in NETs, wound healing assay was used to detect the migration of Cal27 and HN6 cells. E, F After inhibiting NE, MMP 9 and CG in NETs, Transwell invasion assay was used to detect the invasion of Cal27 and HN6 cells. (n = 4). (ns P ≥ 0.05, ***P < 0.001, scale bars = 100 μm). CG cathepsin G, MMP9 matrix metalloproteinase 9, NE neutrophil elastase, NET neutrophil extracellular trap, OSCC oral squamous cell carcinoma.