. 2024 Apr 19;11:1367589. doi: 10.3389/fnut.2024.1367589

Table 2.

Trend of significantly differential metabolites in liver.

No.	Sort	Metabolite	Formula	Mode	Adducts	RT	m/z	VIP	Trend
No.	Sort	Metabolite	Formula	Mode	Adducts	RT	m/z	VIP	MOD/CON	TAU/MOD
1	Glycerophospholipids	PE (22:6/P-18:0)	C₄₅H₇₈NO₇P	Neg	M − H	25.26	774.5426	3.13	↑^***	↓^*
2	Glycerophospholipids	GPCho (16:1/16:1)	C₄₀H₇₆NO₈P	Pos	M + Na	24.3	752.5204	3.29	↑^***	↓^*
3	Glycerophospholipids	PC (14:0/0:0)	C₂₂H₄₆NO₇P	Pos	M + H	15.86	468.3087	2.45	↑^***	↓^*
4	Glycerophospholipids	LysoPE (16:1 (9Z)/0:0)	C₂₁H₄₂NO₇P	Pos	M + H	16.11	452.2773	3.39	↑^***	↓
5	Glycerophospholipids	GPEtn (18:0/18:1)	C₄₁H₈₀NO₈P	Neg	M − H	25.86	744.5552	2.31	↑^***	↓
6	Glycerophospholipids	GPEtn (16:1/20:4)	C₄₁H₇₂NO₈P	Neg	M − H	23.5	736.4930	2.44	↑^***	↓
7	Glycerophospholipids	CL (a-13:0/a-25:0/18:2/18:2)	C₈₃H₁₅4O₁₇P₂	Pos	M + H + Na	25.1	754.5362	3.88	↑^***	↓^*
8	Glycerophospholipids	PC (22:4/0:0)	C₃₀H₅₄NO₇P	Pos	M + H	18.51	572.3713	2.42	—	↓^**
9	Glycerophospholipids	PS [16:0/18:2 (9Z, 12Z)]	C₄₀H₇₄NO₁₀P	Neg	M + Na − 2H	23.61	780.4806	1.68	↑^*	↓
10	Glycerophospholipids	PI [16:0/22:5 (7Z, 10Z, 13Z, 16Z, 19Z)]	C₄₇H₈₁O₁₃P	Pos	M + ACN + Na	23.7	948.5567	2.73	↑^*	↓^*
11	Glycerophospholipids	PE (16:0/0:0)	C₂₁H₄₄NO₇P	Pos	M + H	17.71	454.2928	1.87	↑^**	↓^*
12	Glycerophospholipids	GPCho (17:1/20:5)	C₄₅H₇₈NO₈P	Pos	M + Na	24.44	814.5352	2.88	↑^**	↓
13	Glycerophospholipids	Choline Glycerophosphate	C₈H₂₀NO₆P	Pos	M + H	1.00	258.1105	1.89	↓^*	—
14	Diglycerides	DG [16:1 (9Z)/16:1 (9Z)/0:0]	C₃₅H₆₄O₅	Pos	M + H	24.37	587.4643	1.92	↑^***	↓^*
15	Diglycerides	DG [16:0/16:1 (9Z)/0:0](iso2)	C₃₅H₆₆O₅	Pos	M + H	25.07	589.4800	2.94	↑^***	↓^*
16	Diglycerides	DG [15:0/20:5 (5Z, 8Z, 11Z, 14Z, 17Z)/0:0]	C₃₈H₆₄O₅	Pos	M + CH₃OH + H	23.24	633.5068	2.42	↑^***	↓^**
17	Diglycerides	DG [12:0/18:1 (9Z)/0:0](iso2)	C₃₃H₆₂O₅	Pos	M + H	24.26	561.4488	3.39	↑^***	↓^*
18	Amino acids	Tiglylglycine	C₇H₁₁NO₃	Neg	M − H	3.00	156.0667	2.89	—	↑^*
19	Amino acids	2-Methylindole	C₉H₉N	Pos	M + H	7.29	132.0810	2.31	↓^**	↑^*
20	Sphingolipids	SM [d18:1/22:1 (13Z)]	C₄₅H₈₉N₂O₆P	Neg	M + FA − H	27.13	829.6445	3.61	↑^*	↓^*
21	Sphingolipids	SM (d14:1/20:0)	C₃₉H₇₉N₂O₆P	Pos	M + Na	24.93	725.5566	1.84	↑^*	↓^*
22	Bile acid	Chenodeoxycholic acid	C₂₄H₄₀O₄	Pos	M + NH₄	13.84	410.3266	1.52	↑^*	—
23	Fatty acid	Docosadienoate (22:2n6)	C₂₂H₄₀O₂	Pos	M + H	17.64	319.2997	1.61	↑^**	↑^**
24	Other	1-Methyladenosine	C₁₁H₁₅N₅O₄	Pos	M + H	1.07	282.1197	2.63	↑^*	↓^*
25	Other	Adenosine 3′-monophosphate	C₁₀H₁₄N₅O₇P	Pos	M + H	1.10	348.0710	2.12	↑^**	↓^**
26	Other	Creatinine	C₄H₇N₃O	Pos	M + H	1.00	114.0666	1.65	—	↓^**

^*p < 0.05, ^**p < 0.01, and ^***p < 0.001. CON, the control group; MOD, the model group; TAU, the taurine group.