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The Danazol-induced idiopathic central precocious puberty (ICPP) rat model was successfully constructed and ZBDH increased the vaginal opening time. (A) The flow chart of the animal experiment was shown; (B) the vaginal opening time of rats in each group was detected; (C) the normal estrus cycle was displayed. **p < 0.01, compared with the control group; ##p < 0.01, compared with the ICPP group.
