Table 1.
Aggregate characteristics of the colon cancer cohorts included in the analysis
| Dataset | Sample number, n (%) | Age, years, mean ± SD | Relapse-free survival |
Overall survival |
Male, n (%) | Stage, n (%) |
MSI, n (%) |
Location, n (%) |
Mutations, n (%) |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Months, mean ± SD | Events, n (%) | Months, mean ± SD | Events, n (%) | I | II | III | IV | Stable | Stable/low | High | Proximal | Distal | BRAF | KRAS | TP53 | ||||
| GSE12945 | 62 (2.9) | 64.5 ± 11.8 | 45.2 ± 14.1 | 12 (19.4) | 42.2 ± 16.0 | 12 (19.4) | 28 (45.2) | 13 (21.0) | 23 (37.1) | 21 (33.9) | 5 (8.1) | N/A | N/A | N/A | 0 (0) | 33 (100) | N/A | N/A | N/A |
| GSE13294 | 155 (7.3) | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | 77 (49.7) | 0 (0) | 78 (50.3) | N/A | N/A | N/A | N/A | N/A |
| GSE14333 | 123 (5.8) | 67.0 ± 11.5 | 39.7 ± 23.8 | 22 (22.2) | N/A | N/A | 72 (58.5) | 22 (17.9) | 43 (35.0) | 37 (30.1) | 21 (17.1) | N/A | N/A | N/A | 47 (39.2) | 73 (60.8) | N/A | N/A | N/A |
| GSE143985 | 91 (4.3) | N/A | 70.1 ± 37.6 | 15 (16.5) | N/A | N/A | N/A | 0 (0) | 55 (60.4) | 36 (39.6) | 0 (0) | 85 (94.4) | 0 (0) | 5 (5.6) | N/A | N/A | 2 (2.2) | 35 (38.5) | 53 (58.2) |
| GSE17538 | 232 (10.9) | 64.7 ± 13.4 | 47.2 ± 29.5 | 55 (31.1) | 50.6 ± 33.7 | 92 (39.7) | 122 (52.6) | 28 (12.1) | 72 (31.0) | 76 (32.8) | 56 (24.1) | N/A | N/A | N/A | 78 (47.0) | 88 (53.0) | N/A | N/A | N/A |
| GSE18088 | 53 (2.5) | 65.4 ± 12.2 | N/A | 13 (24.5) | N/A | N/A | 26 (49.1) | N/A | N/A | N/A | N/A | 34 (64.2) | 0 (0) | 19 (35.8) | 28 (52.8) | 25 (47.2) | N/A | N/A | N/A |
| GSE26682 | 331 (15.5) | 72.2 ± 10.8 | N/A | N/A | N/A | N/A | 179 (54.1) | N/A | N/A | N/A | N/A | 218 (65.9) | 78 (23.6) | 35 (10.6) | N/A | N/A | N/A | N/A | N/A |
| GSE29621 | 2 (0.1) | N/A | 70.5 ± 12.7 | 1 (50.0) | 73.8 ± 17.2 | 1 (50.0) | 1 (50.0) | 0 (0) | 1 (50.0) | 1 (50.0) | 0 (0) | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| GSE30540 | 35 (1.6) | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| GSE31595 | 37 (1.7) | 74.1 ± 10.1 | 47.7 ± 30.2 | 8 (21.6) | N/A | 11 (29.7) | 15 (40.5) | 0 (0) | 20 (54.1) | 17 (45.9) | 0 (0) | N/A | N/A | N/A | 23 (62.2) | 14 (37.8) | N/A | N/A | N/A |
| GSE33114 | 90 (4.2) | 70.6 ± 12.8 | 40.4 ± 26.5 | 20 (22.2) | N/A | N/A | 42 (46.7) | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| GSE34489 | 33 (1.5) | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| GSE37892 | 65 (3.0) | 68.6 ± 11.8 | 41.7 ± 21.0 | 13 (20.0) | N/A | N/A | 34 (52.3) | 0 (0) | 55 (84.6) | 10 (15.4) | 0 (0) | 0 (0) | 52 (100) | 0 (0) | 29 (45.3) | 35 (54.7) | 0 (0) | 22 (33.8) | 8 (12.3) |
| GSE38832 | 70 (3.3) | N/A | 27.8 ± 19.8 | 6 (11.1) | 26.2 ± 19.2 | 11 (15.7) | N/A | 14 (20.0) | 21 (30.0) | 19 (27.1) | 16 (22.9) | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| GSE39582 | 514 (24.1) | 66.6 ± 13.3 | 48.2 ± 41.5 | 170 (33.6) | 56.8 ± 39.6 | 177 (34.7) | 281 (54.7) | 33 (6.5) | 213 (41.8) | 204 (40.0) | 60 (11.8) | 0 (0) | 439 (85.4) | 75 (14.6) | 202 (39.3) | 312 (60.7) | 51 (9.9) | 195 (37.9) | 182 (35.4) |
| GSE41258 | 185 (8.7) | 63.5 ± 13.9 | 66.4 ± 47.2 | 36 (30.5) | 68.4 ± 48.3 | 93 (50.3) | 98 (53.0) | 28 (15.1) | 50 (27.0) | 49 (26.5) | 58 (31.4) | 117 (63.2) | 33 (17.8) | 35 (18.9) | 32 (35.6) | 58 (64.4) | N/A | N/A | N/A |
| GSE92921 | 59 (2.8) | N/A | 72.1 ± 36.1 | 6 (10.2) | N/A | N/A | N/A | 0 (0) | 43 (72.9) | 16 (27.1) | 0 (0) | 53 (91.4) | 0 (0) | 5 (8.6) | N/A | N/A | 2 (3.4) | 23 (39.0) | 35 (59.3) |
| All samples | 2,137 (100) | 67.5 ± 12.9 | 49.8 ± 37.1 | 377 (26.7) | 54.6 ± 39.3 | 397 (36.2) | 898 (53.0) | 138 (10) | 596 (42) | 486 (34) | 216 (15) | 584 (41) | 602 (42) | 252 (18) | 439 (41) | 638 (59) | 55 (8) | 275 (40) | 278 (55) |
SD, standard deviation; N/A, not available.