Figure 2.

Timeline of bioactive restorative materials. (A) In the upper section, the mileposts in developing dental materials commercialized in the market with claimed bioactivity toward secondary caries prevention. In the lower section, the mileposts of the innovative approaches and investigations for developing new bioactive resin-based materials. (B) Some highlighted steps in the design and faced drawbacks in the development of new resin-based formulations proposed to convey bioactivity to dental resin materials, such as resin composites, adhesives, and luting agents.