Table 2.
Comparative analysis of radiological features of IMA and INMA within the training and test cohorts.
| Variables | Training cohort |
Test cohort |
||||||
|---|---|---|---|---|---|---|---|---|
| Total (n = 376) | INMA (n = 344) | IMA (n = 32) | p-value | Total (n = 162) | INMA (n = 144) | IMA (n = 18) | p-value | |
| Location, N (%) | 0.878 | 0.504 | ||||||
| RUL | 109 (29) | 102 (29.7) | 7 (21.9) | 46 (28.4) | 39 (27.1) | 7 (38.9) | ||
| RLL | 81 (21.5) | 73 (21.2) | 8 (25) | 45 (27.8) | 39 (27.1) | 6 (33.3) | ||
| RML | 33 (8.8) | 30 (8.7) | 3 (9.4) | 10 (6.2) | 9 (6.2) | 1 (5.6) | ||
| LUL | 94 (25) | 86 (25) | 8 (25) | 32 (19.8) | 31 (21.5) | 1 (5.6) | ||
| LLL | 59 (15.7) | 53 (15.4) | 6 (18.8) | 29 (17.9) | 26 (18.1) | 3 (16.7) | ||
| Boundary, N (%) | 0.297 | 0.401 | ||||||
| Ill-defined | 84 (22.3) | 74 (21.5) | 10 (31.2) | 37 (22.8) | 27 (18.8) | 10 (55.6) | ||
| Well-defined | 292 (77.7) | 270 (78.5) | 22 (68.8) | 125 (77.2) | 117 (81.2) | 8 (44.4) | ||
| Shape, N (%) | 0.984 | 0.14 | ||||||
| Irregular | 205 (54.5) | 187 (54.4) | 18 (56.2) | 86 (53.1) | 73 (50.7) | 13 (72.2) | ||
| Others | 171 (45.5) | 157 (45.6) | 14 (43.8) | 76 (46.9) | 71 (49.3) | 5 (27.8) | ||
| Lobulation, N (%) | 0.24 | 0.075 | ||||||
| Absence | 84 (22.3) | 80 (23.3) | 4 (12.5) | 38 (23.5) | 37 (25.7) | 1 (5.6) | ||
| Presence | 292 (77.7) | 264 (76.7) | 28 (87.5) | 124 (76.5) | 107 (74.3) | 17 (94.4) | ||
| Spiculation, N (%) | 0.117 | 0.782 | ||||||
| Absence | 110 (29.3) | 105 (30.5) | 5 (15.6) | 44 (27.2) | 40 (27.8) | 4 (22.2) | ||
| Presence | 266 (70.7) | 239 (69.5) | 27 (84.4) | 118 (72.8) | 104 (72.2) | 14 (77.8) | ||
| Vascular Convergence Sign, N (%) | 0.001 | 0.019 | ||||||
| Absence | 191 (50.8) | 184 (53.5) | 7 (21.9) | 89 (54.9) | 83 (57.6) | 6 (33.3) | ||
| Presence | 185 (49.2) | 160 (46.5) | 25 (78.1) | 73 (45.1) | 61 (42.4) | 12 (66.7) | ||
| Vacuole Sign, N (%) | 0.89 | 0.144 | ||||||
| Absence | 308 (81.9) | 281 (81.7) | 27 (84.4) | 123 (75.9) | 112 (77.8) | 11 (61.1) | ||
| Presence | 68 (18.1) | 63 (18.3) | 5 (15.6) | 39 (24.1) | 32 (22.2) | 7 (38.9) | ||
| Pleural Indentation, N (%) | 0.032 | 0.048 | ||||||
| Absence | 87 (23.1) | 85 (24.7) | 2 (6.2) | 42 (25.9) | 39 (27.1) | 3 (16.7) | ||
| Presence | 289 (76.9) | 259 (75.3) | 30 (93.8) | 120 (74.1) | 105 (72.9) | 15 (83.3) | ||
| Sex, N (%) | 1 | 0.803 | ||||||
| Absence | 176 (46.8) | 161 (46.8) | 15 (46.9) | 81 (50) | 71 (49.3) | 10 (55.6) | ||
| Presence | 200 (53.2) | 183 (53.2) | 17 (53.1) | 81 (50) | 73 (50.7) | 8 (44.4) | ||
| Age, Median (Q1, Q3) | 61 (54, 67) | 61 (54, 67) | 59 (52.5, 65.2) | 0.285 | 61 (54, 67.8) | 60 (53.8, 67) | 64 (56.8, 71) | 0.191 |
| Size, Median (Q1, Q3) | 20.8 (15, 26.2) | 20.2 (14.6, 25.6) | 23.5 (21.1, 30) | <0.001 | 20.4 (15.2, 27.8) | 19.5 (15, 25.9) | 29 (22.9, 30) | <0.001 |
Abbreviation: LUL Left Upper Lobe, LLL Left Lower Lobe, RUL Right Upper Lobe, RML Right Middle Lobe, RLL Right Lower Lobe, IMA Invasive Mucinous Adenocarcinoma, LADC Lung Adenocarcinoma, INMA invasive non-mucinous adenocarcinoma.