Table 2.

Effect of weight reduction on lipid levels. Variance exists in the degree of lipid effects of weight reduction, depending on the studies selected for meta-analyses. The overall message is that weight reduction generally reduces blood LDL-C and triglycerides, and raises HDL-C, with the effects dependent on the amount of weight reduction.

Study	Weight & lipid effects	Type of study (reference)
Dattilo, Kris-Etherton (1992)	For every 1-kg decrease in body weight: •↓ LDL-C 0.77 mg/dL •↓ TG 1.33 mg/dL •↓ HDL-C 0.27 mg/dL (during active weight reduction) •↑ HDL-C 0.35 mg/dL (after stabilization of body weight)	Meta-analysis [190]
Zomer (2016)	Overall lipid effects regarding interventions that promote weight reduction: •↓ LDL-C 8 mg/dL •↓Triglycerides 12 mg/dL •↔ HDL-C	Meta-analysis [191]
Hasan (2020)	For every 1 kg decrease in body weight with lifestyle interventions (“diet, exercise, or both”): •↓ LDL-C 1.28 mg/dL •↓ TG 4.0 mg/dL •↑ HDL-C 0.46 mg/dL	Meta-analysis [192]

HDL-C: High-density lipoprotein cholesterol

LDL-C: Low-density lipoprotein cholesterol

TG: Triglycerides

↓: Decreases

↑: Increases

↔: Neutral effect