Table 1.
Demographic and Baseline Characteristics
| Parameter | Patients (n = 12) |
|---|---|
| Age, median (range), years | 9 (4–18) |
| Female sex, n (%) | 8 (66.7) |
| Race, n (%) | |
| White | 9 (75.0) |
| Unknown | 2 (16.7) |
| Other | 1 (8.3) |
| Body weight, median (range), kg | 34.7 (15.3–63.7) |
| KPS/LPS, median (range) | |
| <80 | 3 (25.0) |
| ≥80 | 9 (75.0) |
| Time from diagnosis, median (range), month | 5.9 (3.0–13.1) |
| Primary tumor location, n (%) | |
| Pons | 8 (66.7) |
| Thalamus | 2 (16.7) |
| Midbrain | 1 (8.3) |
| Spinal cord | 1 (8.3) |
| Diagnosis, n (%) | |
| Diffuse midline glioma, H3 K27M-mutant | 8 (66.7) |
| DIPG (biopsied) | 4 (33.3) |
| Non-DIPG (biopsied) | 4 (33.3) |
| DIPG (nonbiopsied) | 4 (33.3) |
| Multifocal disease, n (%) | |
| Yes | 2 (16.7) |
| No | 10 (83.3) |
| Disease status, n (%) | |
| Post radiation, not recurrent | 8 (66.7) |
| Recurrent | 4 (33.3) |
| H3 K27M mutation method, n (%) | |
| Immunohistochemistry | 5 (41.7) |
| Next-generation sequencing | 3 (25.0) |
| H3.3 K27M mutation | 3 (25.0) |
| H3.1 K27M mutation | 0 |
| Unknown | 4 (33.3) |
| Number of recurrences, n (%) | |
| 0 | 8 (66.7) |
| 1 | 2 (16.7) |
| ≥2 | 2 (16.7) |
| Time from prior radiation, median (range), days | 60.5 (29.0–290) |
| Re-irradiation, n (%) | 3 (25.0) |
| Dexamethasone daily dose, median (range), mg | 0.2 (0–4) |