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. 2023 Aug 17;26(Suppl 2):S136–S154. doi: 10.1093/neuonc/noad144

Figure 1.

Figure 1.

Expression of dordaviprone cellular targets across pediatric cancers, compared with diffuse gliomas. (A) DRD2 and (B) CLPP mRNA expression in diffuse glioma (including diffuse midline glioma, diffuse pontine glioma, and other high-grade gliomas), low-grade glioma, medulloblastoma, ependymoma, neuroblastoma, osteosarcoma, kidney, adrenal gland, AML (acute myeloid leukemia), ALL (acute lymphoid leukemia), and NBM (normal bone marrow). Diseases are grouped into BT (brain tumor), ST (solid tumor), and HM (hematological malignancies). RNA expression data were analyzed from publicly available data (normalized fragments per kilobase of transcript per million mapped reads [FPKM]).46 (C) CLPP protein expression (z-score) across pediatric central nervous system cancers analyzed from publicly available data.49 The dotted line is the median expression level for diffuse glioma, while turquoise dots are less than the dotted line and orange have the median above the dotted line. Statistical significance determined compared only to diffuse gliomas (one-way ANOVA, *P < .05,**P < .01,***P < .001,****P < .0001).