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. 2024 May 3;24:557. doi: 10.1186/s12885-024-12313-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — IMPDH1 is highly expressed in ESCC tissue and is related to the patient’s prognosis. (A-C) IMPDH1 expression in pan-cancer using TIMER2.0 (A), UALCAN (B) and GEPIA (C) portals. (D-E) IMPDH1 expression in normal and esophageal carcinoma (ESCA) tissues using GEPIA (D) and UALCAN (E) portals. (F) IMPDH1 expression in esophageal squamous cell carcinoma (n = 95) and adenocarcinoma (n = 89) tissues using UALCAN portals. (G) Kaplan-Meier analyses of OS for esophageal carcinoma (ESCA) patients with high (n = 36) or low (n = 45) tumor IMPDH1 expression using TCGA database. The median survival time for low and high IMPDH1 expression cohort is 42.1 months and 25.5 months respectively. The statistical difference was assessed with the unpaired nonparametric Mann–Whitney U test in A, B, C, D, E and F; and the Logrank test for G. *p < 0.05, **p < 0.01; NS, not statistically significant