Table 4.

The EQ-5D-5L health utility score (HUS) and EQ-VAS score of various subgroups (clinical characteristics)

Variables	N	HUS		VAS score
		Mean	SD	Mean	SD
Initial symptom
Hemoglobinuria
Yes	210	0.75	0.22	60.42	19.63
No	119	0.78	0.19	66.48	17.83
Anemia (Fatigue, Tachycardia, Shortness of breath, Headache)
Yes	201	0.73	0.23	60.30	18.95
No	128	0.82	0.18	66.23	19.09
Jaundice
Yes	154	0.74	0.22	60.95	19.68
No	175	0.78	0.20	64.07	18.69
Pancytopenia, bone marrow hematopoietic failure
Yes	123	0.73	0.24	61.38	20.32
No	206	0.78	0.19	63.34	18.50
Abdominal pain
Yes	58	0.68	0.28	56.72	20.91
No	271	0.78	0.19	63.87	18.61
Back pain
Yes	47	0.61	0.33	54.36	19.15
No	282	0.79	0.18	63.99	18.89
Erectile dysfunction
Yes	37	0.76	0.24	63.92	17.94
No	292	0.76	0.21	62.45	19.37
Dysphagia
Yes	27	0.66	0.29	56.37	15.91
No	302	0.77	0.20	63.17	19.39
Cognitive disorder
Yes	5	0.81	0.13	53.40	33.31
No	324	0.76	0.22	62.75	18.95
Several common complications during the past year
Stones
Yes	50	0.71	0.21	60.02	22.24
No	279	0.77	0.21	63.08	18.61
Thrombosis
Yes	24	0.59	0.32	50.42	24.93
No	305	0.78	0.20	63.57	18.38
Renal failure
Yes	9	0.58	0.33	55.11	22.05
No	320	0.77	0.21	62.82	19.11
Pulmonary hypertension
Yes	8	0.64	0.24	48.88	23.64
No	321	0.77	0.21	62.95	18.99
Bone marrow failure (BMF)
Yes	7	0.44	0.28	40.14	10.88
No	322	0.77	0.21	63.10	19.05
Necrosis of the femoral head
Yes	4	0.75	0.11	53.75	22.04
No	325	0.76	0.22	62.72	19.17
Misdiagnosis
Yes	111	0.75	0.24	62.68	17.83
No	218	0.77	0.20	62.58	19.90
The latest pathological grade
Classic PNH	239	0.77	0.21	63.06	18.07
PNH in the setting of another specified bone marrow disorder	73	0.74	0.21	58.81	21.31
Sub-clinical PNH	17	0.81	0.23	72.59	21.87
Total	329	0.76	0.21	62.61	19.20

HUS: Health utility score

VAS: Visual analogue scale

SD: Standard deviation