Table 5.
Factors associated with EQ-5D-5L health utility score of Chinese PNH patients
| Independent variable | Coefficient (95%CI) | P | VIF |
|---|---|---|---|
| Constant | 0.908 (0.781,1.035) | 0.000 | |
| Gender (Male) | |||
| Female | -0.044(-0.091,0.003) | 0.067 | 1.258 |
| Age | -0.002(-0.004,0.001) | 0.228 | 1.604 |
| Ethnicity (Han) | |||
| Other ethnicities | -0.001(-0.101,0.100) | 0.988 | 1.079 |
| Educational status (Junior college, college degree) | |||
| Junior high school and below | -0.031 (-0.091,0.029) | 0.315 | 1.420 |
| High school, technical secondary school or vocational high school, etc. | -0.011 (-0.071,0.049) | 0.720 | 1.343 |
| Postgraduate or above | 0.010 (-0.080,0.101) | 0.823 | 1.129 |
| Marital status (Have a partner) | |||
| Single | 0.011 (-0.046,0.067) | 0.716 | 1.727 |
| Fertility situation (No) | |||
| Yes | 0.013 (-0.046,0.073) | 0.654 | 2.005 |
| School/employment status (No) | |||
| Yes | 0.046 (-0.006,0.099) | 0.083 | 1.534 |
| Total personal income for the past year (<35,128 CNY) | |||
| ≥ 35,128 CNY | 0.048 (-0.009,0.104) | 0.096 | 1.657 |
| Hemoglobinuria (No) | |||
| Yes | -0.015 (-0.063,0.033) | 0.527 | 1.219 |
| Anemia (Fatigue, Tachycardia, Shortness of breath, Headache) (No) | |||
| Yes | -0.057 (-0.105,-0.010) | 0.017 | 1.208 |
| Jaundice (No) | |||
| Yes | 0.006 (-0.042,0.055) | 0.804 | 1.346 |
| Pancytopenia, bone marrow hematopoietic failure (No) | |||
| Yes | -0.030 (-0.076,0.016) | 0.199 | 1.133 |
| Abdominal pain (No) | |||
| Yes | -0.003 (-0.065,0.060) | 0.935 | 1.301 |
| Back pain (No) | |||
| Yes | -0.146 (-0.214,-0.078) | 0.000 | 1.317 |
| Erectile dysfunction (No) | |||
| Yes | 0.029 (-0.047,0.105) | 0.456 | 1.331 |
| Dysphagia (No) | |||
| Yes | -0.052 (-0.137,0.032) | 0.226 | 1.236 |
| Stones (No) | |||
| Yes | -0.040 (-0.101,0.021) | 0.198 | 1.102 |
| Thrombosis (No) | |||
| Yes | -0.161 (-0.245,-0.077) | 0.000 | 1.101 |
| Misdiagnosis (No) | |||
| Yes | -0.036 (-0.083,0.010) | 0.122 | 1.097 |
| The latest pathological grade (Classic PNH) | |||
| PNH in the setting of another specified bone marrow disorder | -0.028 (-0.082,0.026) | 0.307 | 1.154 |
| Sub-clinical PNH | -0.009 (-0.109,0.091) | 0.862 | 1.129 |
| Adjusted R 2 | 0.193 |
CI: Confidence interval
VIF: Variance inflation factor
P: p value
35,128: The 2021 annual average per capita disposable income of Chinese residents
CNY: Chinese Yuan