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. 2024 Apr 2;300(5):107257. doi: 10.1016/j.jbc.2024.107257

Figure 5.

Figure 5

Combined deletion of RAP2 GTPase and MAP4Ks does not further potentiate Hippo deficiency compared with deletion of RAP2 GTPase or MAP4Ks alone.A, two different sets of sgRNAs targeting RAP2A, RAP2B, and RAP2C genes, as previously described in Ref. (11), were used to delete these three genes in MAP4K4/6/7 tKO cells. Two clones were expanded for further analysis. B–D, WT, MAP4K4/6/7 tKO, and RAP2A/B/C-MAP4K4/6/7 6KO cells were treated with LatB (B), serum starvation (C), and 2-DG (D) for 30 min.