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Removing the C-terminal glutamine-rich domain inhibits the ability of p300 to stimulate insulin enhancer-driven activity. HIT T-15 cells were transfected with 2.5 μg of RIPE3:LUC and 20 μg of either pCMVβ-p300 or pCMVβ-p300ΔQ. The activity ± standard error of the mean) is presented relative to RIPE3:LUC alone.
