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. 2024 Apr 19;14:1364958. doi: 10.3389/fonc.2024.1364958

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Copyright © 2024 Lechner, Kumbrink, Walz, Jung, Baumeister and Flach

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overview of somatic variants identified in HNSCC, HGD, MGD, LGD, hyperplasia and normal tissue from patients 4 and 5. (A) Oncoplot of the most frequently mutated genes. This shows a list of genes arranged based on the total number of variants in each gene with the percentage representing the ratio of samples with its genetic alteration to the total number of samples. Type of mutation, sample histology and anatomical localization are explained in the legend. The variant prevalence and spectrum of TP53 (B), NOTCH1 (C), and NOTCH3 (D) genes in this cohort. Green circles indicate missense mutations, black circles truncating mutations, and orange circles splice sites. HNSCC, Head and Neck Squamous Cell Carcinoma; HGD, high grade dysplasia; MGD, medium grade dysplasia; LGD, low grade dysplasia.