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. 2024 Mar;34(3):441–453. doi: 10.1101/gr.278550.123

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© 2024 Reis-Cunha et al.; Published by Cold Spring Harbor Laboratory Press

This article, published in Genome Research, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.

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Figure 4. — TASC carry more potential for increased functional variation but purge highly deleterious mutations more efficiently than other chromosomes. (A) SNP-derived allele frequency (DAF) along TASC. Each dot corresponds to a SNP; the y-axis to its DAF and the x-axis to Leish Chr 31 positions. (B,C) Boxplot (B) and density plot (C) comparing DAF from TASC and other chromosomes. (D) Proportion of ancestral homozygous (ancestral), heterozygous (Het), or derived homozygous (derived) genotypes in the 113 L. donovani isolates. Distribution of derived allele read depth (DARD) in heterozygous positions on TASC and other chromosomes, separated by high and low impact (E) or by −3 to 3 impact (F).