Table 3:
Following Neoadjuvant Treatment | ||||||||||
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# | Procedure | Neoadjuvant Treatment | CA19–9 Response* | Tumor Regression on Cross Sectional Imaging | Final Pathology | TBR | Neck Margin Fluorescence | Retroperitoneal Margin Fluorescence | Frozen Section Diagnosis | Final Margin Status |
1 | PD | None | -- | -- | PDAC | 7.71 | Yes | No | N/A | (+) neck, (−) uncinate |
2 | DP | None | -- | -- | PDAC | 3.77 | Yes | No | N/A | (+) neck |
3 | PD | None | -- | -- | Intrapancreatic cholangiocarcinoma | 2.08 | Yes | No | (+) adenocarcinoma |
(−) |
4 | DP | None | -- | -- | PDAC | 12.43 | No | No | N/A | (−) |
5 | PD | None | -- | -- | PDAC | 2.13 | No | No | (−) | (−) |
7 | PD | None | -- | -- | PDAC | 3.29 | Yes | No | N/A | (+) neck, (−) uncinate |
10 | DP | CRT | Yes | Yes | PDAC, 10% viable tumor | 1.25 | No | No | N/A | (−) |
11 | DP | No | -- | -- | 4.20 | No | No | (−) | (−) | |
13 | DP | CO | Yes | No | PDAC, 100% viable tumor | 4.63 | No | No | N/A | (−) |
13 | PD | CO | Yes | No | PDAC, 100% viable tumor | 2.76 | Yes | No | N/A | (+) neck, (−) uncinate |
16 | DP | CRT | Yes | Yes | PDAC, 100% viable tumor | 4.83 | Yes | No | N/A | (+) neck |
17 | PD | No | -- | -- | PDAC | 3.38 | No | No | (+) HGD | (−) |
19 | PD | CO | No | No | PDAC, 100% viable tumor | 5.06 | Yes | No | (−) | (−) |
* >50% reduction in CA19–9 immediately prior to surgery
Abbreviations: TBR tumor-to-background ratio, PD pancreaticoduodenectomy, PDAC pancreatic ductal adenocarcinoma, DP distal pancreatectomy, CRT chemoradiotherapy, CO chemotherapy only, HGD high grade dysplasia.