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. 2024 Mar 1;147(5):1644–1652. doi: 10.1093/brain/awae061

Figure 2.

Figure 2

Cryo-EM analysis shows a high similarity between α-synuclein (α-syn) fibrils used to develop vaccine candidates and those used to challenge TgM83+/− mice (Protein Data Bank ID 8OQ1). (A) A cross-section through the reconstructed density map. (B) Superposition of the final density map (grey mesh) and the atomic model (green sticks). The labels indicate the N- and C-terminal residues. (C) Superposition of two opposing subunits or only a single chain (D) extracted from the atomic model of the N-acetylated human α-syn fibril and a previously determined wild-type α-syn fibril (shown in green) with Protein Data Bank (PDB) ID 6H6B (shown in cyan). Residues selected to model the vaccine candidates α-SC6, α-SC8 and α-SC9 are labelled.