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. 2024 Feb 22;147(5):1784–1798. doi: 10.1093/brain/awae063

Figure 3.

Figure 3

Tissue-specific changes in the instability index and CAG repeat mode of the of the CAG repeat profiles in zQ175, zQ175:Msh3+/− and zQ175:Msh3−/− mice. (A) Instability index quantified for the GeneMapper traces for each brain region and tissue normalized to P12 ear sample for each genotype. (A) Stepwise reduction in the instability index was observed for each brain region/tissue with the reduction and loss in Msh3 expression. (B) Quantification of the change in mode from the P12 ear sample. Modal CAG was reduced with Msh3 genotype, in all regions apart from striatum, heart and liver. n = 8/genotype, 2–3 technical replicates for each mouse. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001. Box and whisker plots represent median and 25th and 75th percentiles with bars drawn from minimum to maximum. Statistical analysis was mixed-effects model (REML), with Tukey's correction for multiple comparisons. The test statistic, degrees of freedom and P-values are summarized in Supplementary Table 4.