Table 2.

Volume changes during aging

Linear Group
	${\mathit{g}}_{\mathit{y}}^{\mathit{L}}$ %, n = 2,458	${\mathit{g}}_{\mathit{y}}^{\mathit{L}}\text{M}$ %, n = 1,113	${\mathit{g}}_{\mathit{y}}^{\mathit{L}}\text{F}$ %, n = 1,345	$\%\hspace{0.17em}{\mathit{g}}_{\mathit{y}}^{\mathit{L}}\text{M}-\%{\mathit{g}}_{\mathit{y}}^{\mathit{L}}\text{F}$
Accumbens	−0.510	−0.543	−0.483	−0.060
Caudate	−0.190	−0.183	−0.134	−0.049
Cerebellum	−0.155	−0.347	−0.288	−0.059
Putamen	−0.314	−0.235	−0.156	−0.080

Quadratic Group
Region	V, yr, n = 2,458	${\mathit{V}}_{\text{M}}$, n = 1,113	${\mathit{V}}_{\text{F}}$, n = 1,345	${\mathit{V}}_{\text{M}}-{\mathit{V}}_{\text{F}}$
Amygdala	32.4	28.8	34.4	−5.6
Brainstem	51.8	53.0	51.5	1.5
Pallidum	37.9	31.0	40.9	−9.9
Thalamus	28.0	18.7	31.3	−12.6
Ventral diencephalon	32.7	31.0	35.0	−4.0

Top: linear percent volume change per year for males (M) and females (F). P < 0.001 for all male and female volume vs. age regressions. Bottom: estimated age (year) V at the vertex of the quadratic function (Eq. 5). $V_{\text{M}}$, $V_{\text{F}}$ estimates for males and females, respectively.