FIG. 7.

HNF-1α-null mice are not resistant to insulin treatment. Hnf-1α^+/− mice (A) and Hnf-1α^−/− mice (B) were administered phosphate-buffered saline (PBS) or insulin solution intraperitoneally at a dosage of 2 mU/mg of body weight/10 μl. Before (▪) and 30 min after (▨) insulin administration, 3 μl of blood was taken from the tail vein of each animal and monitored for glucose concentration. The pretreatment glucose level was designated 100%. After treatment, the glucose level was calculated as a percentage of the pretreatment level. The value for each group is the average for the three serum samples. The standard deviation for each group is shown as a vertical line.