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. 2023 Oct 10;325(6):L776–L787. doi: 10.1152/ajplung.00103.2023

Figure 3.

Figure 3.

Grandmaternal allergen exposure during pregnancy alters vagal ganglion DNA methylation at baseline and after allergen sensitization in second-generation offspring. Grandmaternal house dust mite (HDM) sensitization resulted in 211 differentially methylated regions (DMRs) (F0 HDM•F2 Base vs. F0 Veh•F2 Base) in vagal ganglia of F2 offspring at baseline. F2 HDM sensitization alone resulted in 346 DMRs (F0Veh•F2Sens vs. F0 Veh•F2 Base). In contrast, HDM sensitization of F2 mice from HDM-exposed founders resulted in 413 DMRs (F0 HDM•F2 Sens vs. F0 HDM•F2 Base). Only 21 genes were shared between F0 Veh•F2 Sens and F0 HDM•F2 Sens groups. Of these 21 genes, only seven had a matching pattern of hyper- or hypomethylation between lineages. n = 8 total for each group (n = 4 males and n = 4 females).