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. 2023 Oct 17;325(6):L741–L755. doi: 10.1152/ajplung.00428.2022

Figure 6.

Figure 6.

Role for PASMC HIF-1α in limiting vasoconstriction and vascular remodeling of pulmonary arteries through induction of p27. A: in SM22α-genetically altered mouse pulmonary arteries: (i) under normoxia and without PASMC HIF-1α pMLC levels are increased, with wild-type and stabilized PASMC HIF-1α pMLC relative levels are decreased; (ii) under acute hypoxia and without PASMC HIF-1α pMLC levels are further increased, with wild-type PASMC HIF-1α pMLC relative levels are increased, and with stabilized PASMC HIF-1α pMLC levels remain low; (iii) under chronic hypoxia and without PASMC HIF-1α pMLC levels remain high and p27 is not induced, with wild-type PASMC HIF-1a pMLC levels increase and p27 is induced, and with stabilized PASMC HIF-1α pMLC levels remain low, and p27 is highly expressed. B: in IPAH pulmonary arteries pMLC levels are increased, and p27 is not induced in response to hypoxia, and relative to control pulmonary arteries. HIF-1α, hypoxia-inducible factor-1α; IPAH, idiopathic pulmonary arterial hypertension; PASMC, pulmonary artery smooth muscle cell; pMLC, myosin light chain phosphorylation.