Table 2.
Chronic hypoxia studies of SM22α-PHD1/2 mice
| n | Age, mo | Male, % | RVSP, mmHg | HR, beats/min | Weight Gain, g | |
|---|---|---|---|---|---|---|
| Normoxia | ||||||
| SM22α-PHD1/2+/+ | 7 | 4.7 ± 0.9 | 71.4 | 29.0 ± 1.0 | 404.3 ± 24.1 | +2.55 ± 0.41 |
| SM22α-PHD1/2−/− | 7 | 5.2 ± 1.1 | 71.4 | 26.9 ± 1.0 | 374.6 ± 29.8 | +2.03 ± 0.37 |
| Chronic hypoxia | ||||||
| SM22α-PHD1/2+/+ | 7 | 4.6 ± 1.0 | 57.1 | 36.9 ± 1.0§ | 360.1 ± 20.1 | −1.13 ± 0.57§§§ |
| SM22α-PHD1/2−/− | 7 | 5.3 ± 0.9 | 42.9 | 26.9 ± 1.9*** | 354.7 ± 19.2 | −0.90 ± 0.49§§§ |
Values are means ± SE. mo, month; RVSP, right ventricular systolic pressure; mmHg, millimeters of mercury; HR, heart rate; beats/min, beats per minute; g, grams. ***P < 0.001, PHD1/2−/− vs. PHD1/2+/+; §P < 0.05, §§§P < 0.001, chronic hypoxia vs. normoxia; n = 7 mice, normoxia SM22α-PHD1/2+/+; n = 7 mice, normoxia SM22α-PHD1/2−/−; n = 7 mice, hypoxia SM22α- PHD1/2+/+; n = 7 mice, hypoxia SM22α-PHD1/2−/−; n = 18–23, weight gain studies. P values were measured by two-way ANOVA.