Table 2.
Gene expression of growth factors in the temporoparietal cortex.
| Hour | CCAO | Zn + CCAO | Zn + CCAO + Se | |
|---|---|---|---|---|
| Igf-1 | 0 | n.s | 3.3 ± 0.9b | 3.3 ± 0.9b |
| 3 | 6 ± 17b | 3.2 ± 0.08c | 9.2 ± 0.4c | |
| 6 | 4.84 ± 1.8b | 6.82 ± 0.2c | 7.9 ± 2.2c | |
| 24 | 0.51 ± 0.05c | 2.88 ± 0.14c, | 2.83 ± 1.2c,d | |
| 168 | 3.3 ± 0.9b | 2.96 ± 0.28c | 5.2 ± 0.7c | |
| Fgf2 | 0 | n.s | 3.5 ± 1.2c | 8.6 ± 1.8c |
| 3 | 4.5 ± 1.5b | 3.28 ± 0.5c | 10.3 ± 0.7c,d | |
| 6 | n.s | 6.23 ± 1c | 4.9 ± 0.7b | |
| 24 | n.s | n.s | 1.9 ± 0.2c,d | |
| 168 | 2.69 ± 0.49b | 3.11 ± 0.26c | 3.62 ± 0.9b | |
| Bdnf | 0 | n.s | 9.63 ± 1.82c | 23.8 ± 4.9c |
| 3 | 3.99 ± 1.1c | 3.98 ± 1.4b | 18.4 ± 2.7c,d | |
| 6 | 5.93 ± 0.3b | 17 ± 0.8cd | 4.09 ± 2a | |
| 24 | 0.68 ± 0.12b | n.s | 5 ± 1b,d | |
| 168 | 6.11 ± 2b | 5.82 ± 0.57c | 9.19 ± 0.4c | |
| Ngf | 0 | n.s | 15.4 ± 1c | 20.95 ± 3.78c |
| 3 | 4.5 ± 0.62c | 7.7 ± 0.4c,d | 21 ± 1.12c,d | |
| 6 | 7.5 ± 0.44**** | 15.3 ± 3.8c | 12.12 ± 1.21c,d | |
| 24 | 2.87 ± 0.37b | 4.7 ± 0.85c,d | 5.48 ± 1.47c | |
| 168 | 3.43 ± 1.1b | 10 ± 1.44c,d | 10 ± 1.92c,d | |
| Vegf | 0 | n.s | 5.4 ± 0.3c | 4.17 ± 0.54b |
| 3 | n.s | 4.69 ± 0.9b,d | 5.21 ± 0.34c,d | |
| 6 | 2.96 ± 0.6b | 2.8 ± 0.55b | n.s | |
| 24 | n.s | 4.13 ± 2.32a,d | n.s | |
| 168 | 3.57 ± 0.08c | 4.09 ± 0.33c | 4.23 ± 0.44a | |
| Gdnf | 0 | n.s | 2.8 ± 0.9b | 3.68 ± 1b |
| 3 | n.s | n.s | n.s | |
| 6 | 3.23 ± 0.92b | 5.7 ± 1.29c | 3.1 ± 0.45c | |
| 24 | n.s | n.s | n.s | |
| 168 | 2.6 ± 0.7b | 6.13 ± 1.07c,d | 7.8 ± 1.27c,d |
The fold change values of mRNA measured by qPCR Taqman are expressed as median ±SEM of n = 3 for each group and time studied. Two-way ANOVA analysis and Dunnett's post hoc test showed statistical differences of.
a
P < 0.05.
b
P < 0.01.
c
P < 0.0001 compared with the control group without treatment and.
d
P < 0.05, compared with the CCAO group; n.s, not significant v.s. the control group.