Table 2.

Median, range, and p value of the original and optimized distances for the input variables

Variable	Original state		Optimized state		p value
	Median	Range	Median	Range
PP	0.0552	(− 4.38, 5.77)	0.0460	(− 2.75, 2.35)	$3.53\times {10}^{-4}$
HbA1c	0.3823	(− 3.83, 4.69)	0.2932	(− 3.19, 2.13)	$4.60\times {10}^{-21}$
PWV	0.5435	(− 1.01, 4.54)	0.3913	(− 0.84, 1.62)	$2.86\times {10}^{-23}$
AGEs	0.4395	(− 1.52, 5.95)	0.2642	(− 1.27, 2.24)	$3.28\times {10}^{-25}$