Table 1.
Baseline (W0) characteristics by HCV genotype (n = 120).
| Genotype 1 | Genotype 2 | Genotype 4 | Overall | |
|---|---|---|---|---|
| n = 40 n (%) or Median [IQR] |
n = 40 n (%) or Median [IQR] |
n = 40 n (%) or Median [IQR] |
n = 120 n (%) Median [IQR] |
|
| Male gender | 21 (53) | 25 (63) | 19 (48) | 65 (54) |
| Age (year) | 59 [51–64] | 52 [41–60] | 61 [55–63] | 58 [49–63] |
| Country of enrolment | ||||
| Cote d’Ivoire | 27 (68) | 18 (45) | 0 (0) | 45 (38) |
| Cameroon | 4 (10) | 13 (33) | 36 (90) | 53 (44) |
| Senegal | 9 (22) | 9 (22) | 4 (10) | 22 (18) |
| BMI (kg/m2) | 23.6 [19.9–25.9] | 24.3 [21.9–27.6] | 28.0 [24.3–31.2] | 24.9 [22.0–28.4] |
| Alcohol, Yes, < once a day | 2 (5) | 8 (20) | 11 (28) | 21 (18) |
| HIV infection | 8 (20) | 12 (30) | 16 (40) | 36 (30) |
| Liver fibrosis (APRI low > 1) | 9 (23) | 10 (25) | 10 (25) | 29 (24) |
| Cirrhosis (APRI high > 2) | 3 (8) | 6 (15) | 5 (13) | 14 (12) |
| logHCV-RNA (IU/mL) at W0 | 5.8 [5.2–6.3] | 6.0 [5.3–6.4] | 6.4 [5.8–6.7] | 6.0 [5.5–6.6] |
| ALT* (IU/L) at W0 | 50 [36–71] | 46 [26–89] | 49 [39–80] | 47 [36–78] |
| ALT grade at W0 | ||||
| 0 | 23 (58) | 26 (65) | 25 (63) | 74 (62) |
| 1.25–2.50 × ULN¥ | 15 (38) | 7 (18) | 10 (25) | 32 (27) |
| > 2.50–5.00 × ULN | 2 (5) | 5 (13) | 4 (10) | 11 (9) |
| > 5.00–10.00 × ULN | 0 | 2 (5) | 1 (3) | 3 (3) |
| Creatinine (mg/L) at W0 | 7 [6–10] | 9 [8–10] | 8 [7–10] | 8 [7–10] |
| Hemoglobin (g/dL) at W0 | 13 [12–14] | 14 [13–15] | 14 [13, 14] | 14 [12–14] |
*Alanine aminotransferase.
¥Under Limit of Normal.